Prkar1a in the Regulation of Insulin Secretion
نویسندگان
چکیده
منابع مشابه
The role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells
Objective(s):The purpose of this study was to investigate the effects of Noggin on high glucose-induced apoptosis and insulin secretion in pancreatic beta cells. Materials and Methods: Different concentrations of glucose were used to examine their effects on INS-1 rat beta cells in vitro. When specific siRNA targeting Noggin and recombinant Noggin were added, apoptosis and insulin secretion wer...
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Nichols, C. G., and J. C. Koster. Diabetes and insulin secretion: whither KATP? Am J Physiol Endocrinol Metab 283: E403–E412, 2002; 10.1152/ajpendo.00168.2002.—The critical involvement of ATP-sensitive potassium (KATP) channels in insulin secretion is confirmed both by the demonstration that mutations that reduce KATP channel activity underlie many if not most cases of persistent hyperinsulinem...
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15 صفحه اولRegulation of insulin secretion by uncoupling protein.
UCPs (uncoupling proteins) can regulate cellular ATP production by uncoupling oxidative phosphorylation. UCP2 is expressed in islet beta-cells and its induction reduces glucose-stimulated insulin secretion. Under physiological conditions, superoxide, formed as a by-product of respiration, activates UCP2. This leads to reduced ATP production, which impairs closure of the ATP-dependent K+ channel...
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ژورنال
عنوان ژورنال: Hormone and Metabolic Research
سال: 2012
ISSN: 0018-5043,1439-4286
DOI: 10.1055/s-0032-1321866